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Food and Drug Administration panel recommended that rimonabant should not be given the FDA's blessing because of continuing concerns about increased risks for suicidal thoughts among some users. Effects Of The Cannabinoid-1 Receptor Blocker Rimonabant On Weight Reduction And Cardiovascular Risk Factors In Overweight Patients: 1-Year Experience From The RIO-Europe Study. Food and Drug Administration (FDA) Endocrinologic and Metabolic Drugs Advisory Committee did not recommend approval of rimonabant (Zimulti / Accomplia) to the US FDA. A CB1 antagonist called rimonabant is currently marketed overseas for weight loss. 25 percent increase in percent atheroma volume (PAV) in those taking rimonabant, compared to 0. Rimonabant, brand named Acomplia, is an anti-obesity drug that may help treat addiction, the team noted.

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